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The tumor-promoting effect of phorbol esters and the inhibitory effects of staurosporine on the protein kinase C (PKC)-induced proliferation and ODC expression in MCF-7 cells were compared. Phorbol esters and staurosporine at the concentration of 10(-5) M inhibited phorbol 12,13-dibutyrate (PDB) induced MCF-7 cell proliferation in a dose-dependent manner. Staurosporine at the concentration of 10(-5) M inhibited PDB-induced ODC expression in MCF-7 cells. The expression of PKC isozymes increased after treatment with PDB. Staurosporine inhibited the PDB-induced expression of PKC isozymes. Staurosporine at the concentration of 10(-5) M inhibited PDB-induced cell proliferation and ODC expression. Staurosporine at the concentration of 10(-5) M inhibited the PDB-induced expression of PKC isozymes. These results indicate that staurosporine inhibits both the PDB-induced cell proliferation and ODC expression.Q:
when to use woff2/otf2 or normal font in html5
i am using a font that is not supported in iOS, so i am using.woff2 file, and.ttf file for this... i found in my header only one reference to this font and that was
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This is a normal font, and can be applied to text in many browsers.
so can i simply skip the woff2 and just use the normal font, or should i just use.woff2 since it is really a waste to use the other two in my case?
A:
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