The anatomical or functional obstacle is caused due to initiation of re-entry, rise ectopic beats that resulted in the abnormal excitability in myocardial cells. The repolarization process of the cardiac action potential (AP) is controlled by potassium currents, membrane potential, refractoriness of the myocardium which is also determined by potassium channel functions. Both loss and gain of the potassium channel function could lead to arrhythmia. These are three pathophysiological relevant aspects that pro-arrhythmic consequences of malfunction potassium channels in atria and ventricular tissue. It has been resulted due to drug action, disease-induced remodeling and genetic background. The increased risk of sudden cardiac death is due to heart failure and the downregulation of potassium channels. Polymorphism and mutations in genes encoding for atrial potassium channels could be linked with loss of function, gain of function and shortened and prolonged action potential duration. The particular therapeutic challenge has become due to the block of atrial potassium channels when trying to better atrial fibrillation. This arrhythmia has a strong tendency to cause electrical remodeling that affects various potassium channels .
Heart to Heart is a project to crowd-source data about heart rhythms. The organizers hope that this will become the largest heart health initiative in the world, and demonstrate the power of crowd-sourced data. To participate, you simply download an app from the Apple App Store, answer a few demographic questions, and then hold your finger over the camera lens, partially covering the flash. In about 90 seconds, the app will calibrate and record your heart beat data. 2b1af7f3a8