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Models for the regulation and function of SNF-10 in promoting sperm activation. (A) SNF-10 functions in spermatids in response to TRY-5 signaling. TRY-5 (green) acts either directly on SNF-10 (blue) or through an intermediate protein (orange). This signal induces SNF-10's function, which may involve import of cargo or ions (yellow), or participation in protein-protein interactions (not shown). SNF-10 could function either on the cell surface or in MOs. (B) SNF-10 acts prior to activation by importing molecules (yellow) required for the activation process. Once primed, the spermatid can activate in response to a TRY-5-mediated signal. (A,B) The subcellular localization of SNF-10 may be regulated in developing spermatocytes. 153554b96e